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Table 2 Genetic predictors of 5-oxoproline and their association with Intelligence

From: Causal relationships between genetically determined metabolites and human intelligence: a Mendelian randomization study

SNP Gene CHR A1 A2 5-oxoproline Intelligence
Beta SE P value Beta SE P value
rs11986602 EXOSC4 8 A T − 0.0620 0.0029 1.07E−104 − 0.0196 0.0044 9.53E−06
rs9987070 7 C G − 0.0280 0.0059 2.43E−06 − 0.0083 0.0071 0.2381
rs10890517 2 T C − 0.0197 0.0043 3.45E−06 − 0.0139 0.0069 0.0427
rs5764925 22 A G − 0.0160 0.0031 1.91E−07 − 0.0021 0.0050 0.6782
rs13159409 5 T G − 0.0148 0.0032 2.74E−06 − 0.0075 0.0053 0.1535
rs12294182 MICAL2 11 T C 0.0140 0.0029 1.07E−06 0.0019 0.0041 0.6478
rs2068157 AACSP1 5 T C 0.0137 0.0031 8.99E−06 − 0.0037 0.0048 0.4362
rs9964014 DLGAP1 18 T C − 0.0132 0.0025 1.80E−07 − 0.0060 0.0078 0.4388
rs11605366 11 T C − 0.0122 0.0027 7.55E−06 − 0.0111 0.0043 0.0094
rs12143589 1 A G 0.0118 0.0023 3.38E−07 − 0.0024 0.0036 0.5034
rs13013224 LOC105369165 2 C G 0.0113 0.0023 7.04E−07 − 0.0031 0.0035 0.3781
rs306676 13 A G 0.0112 0.0024 2.48E−06 − 0.0027 0.0041 0.5047
rs9650466 MROH1 8 T C 0.0110 0.0020 3.80E−08 0.0046 0.0028 0.0938
rs1001210 ATXN1 6 T C − 0.0106 0.0023 3.80E−−06 − 0.0051 0.0037 0.1678
rs17017431 TRAF5 1 A T 0.0105 0.0023 3.80E−06 0.0022 0.0038 0.5628
rs10853533 SLC14A2 18 A C 0.0103 0.0023 6.09E−06 − 0.0068 0.0043 0.1133
rs2115151 SPATA5 4 A T 0.0103 0.0022 3.75E−06 0.0024 0.0041 0.5561
rs7015048 8 T C 0.0100 0.0015 3.16E−11 − 0.0015 0.0028 0.5864
rs9460424 6 T G − 0.0097 0.0022 9.16E−06 − 0.0053 0.0035 0.1328
rs4646693 LRRK1 15 T C − 0.0090 0.0020 6.80E−06 − 0.0001 0.0054 0.9909
rs8092658 SLC14A2 18 A C − 0.0090 0.0020 6.80E−06 0.0001 0.0028 0.9828
rs1578743 10 A C 0.0075 0.0016 1.70E−06 0.0026 0.0029 0.3664
rs7973508 12 A G − 0.0073 0.0016 5.40E−06 0.0007 0.0030 0.8245
rs12464424 2 T C − 0.0071 0.0016 7.47E−06 0.0055 0.0030 0.0651
rs12611788 GALNT14 2 T C − 0.0070 0.0015 5.51E−06 − 0.0062 0.0029 0.0301
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