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Fig. 4 | Molecular Brain

Fig. 4

From: The de novo CACNA1A pathogenic variant Y1384C associated with hemiplegic migraine, early onset cerebellar atrophy and developmental delay leads to a loss of Cav2.1 channel function

Fig. 4

Recovery from inactivation of CaV2.1 (Δ47), Y1384C (Δ47), CaV2.1 (+ 47) and Y1384C (+ 47) channels. a Fractional recovery from inactivation of CaV2.1 (Δ47), Y1384C (Δ47) channels. b Fractional recovery from inactivation of CaV2.1 (+ 47), Y1384C (+ 47) channels. The numbers in parentheses represent the numbers of cells recorded. Symbols indicate significant difference relative to wild type of the same splicing isoform. Number signs indicate significant difference between CaV2.1 isoforms. Asterisks and number signs denote significance *0.05, **0.01, ##0.01, ###0.001, ####0.0001 (One-way ANOVA and Tukey’s multiple comparison test, with a single pooled variance test)

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