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Fig. 1 | Molecular Brain

Fig. 1

From: Pharmacological blockade of dopamine D1- or D2-receptor in the prefrontal cortex induces attentional impairment in the object-based attention test through different neuronal circuits in mice

Fig. 1

Dopamine D1- and D2-receptor antagonists impair attention in the OBAT by injection into the PFC of mice. a Experimental protocol of the entire procedures. b Protocol for OBAT. c Experimental protocol of OBAT and c-Fos staining. d The exploratory time in the training and e recognition index in the testing of OBAT (vehicle = 8 mice, D1-receptor antagonist = 9 mice, D2-receptor antagonist = 8 mice). f Representative image of the injection site (scale bar: 1000 µm). g Representative image of the c-Fos-positive cells (scale bar: 100 µm). h Schematic brain area of DMS, DLS, cNAc, sNAc, i LSv, BNST, IPAC, SI, j CA1, CA3 and DG referred from the Allen Mouse Brain Atlas. k The c-Fos expression in the heatmap form. * p < 0.05, ** p < 0.01. All data are expressed as means ± SEM. PFC, prefrontal cortex; OBAT, object-based attention test; anterior cingulate cortex (ACC); prelimbic cortex (PrL); infralimbic cortex (IL); dorsomedial striatum (DMS); dorsolateral striatum (DLS); nucleus accumbens core (cNAc), nucleus accumbens shell (sNAc); lateral septal nucleus ventral part (LSv); bed nucleus of the stria terminalis (BNST); interstitial nucleus of the posterior limb of the anterior commissure (IPAC); substantia innominate (SI); cornu ammonis 1 (CA1); cornu ammonis 3 (CA3); dentate gyrus (DG)

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Molecular Brain

ISSN: 1756-6606