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Fig. 5 | Molecular Brain

Fig. 5

From: Cdk5 regulatory subunit-associated protein 1 knockout mice show hearing loss phenotypically similar to age-related hearing loss

Fig. 5

Changes in mitochondrial metabolites in Cdk5rap1-KO cochleae. a Schematic representation of the tricarboxylic acid (TCA) cycle and mitochondrial electron-transport system. Under stress conditions, the mitochondrial respiratory chain complexes’ activities decreased in Cdk5rap1-knockout (KO) mice. b Heatmap analysis (left panel) and principal-component analysis (right panel) as components of metabolome analysis; n = 3 for each genotype (c). Comparison of fumarate, pyruvate, and lactate levels between the cochleae of KO and littermate control (CNT) mice at 4, 12, 20, or 48 weeks of age; n = 3 for each genotype

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Molecular Brain

ISSN: 1756-6606