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Fig. 3 | Molecular Brain

Fig. 3

From: Atg7 deficiency in microglia drives an altered transcriptomic profile associated with an impaired neuroinflammatory response

Fig. 3

Atg7 deficiency drives an altered transcriptomic profile in microglia. a Heat map of up- and downregulated genes comparing three independent replicates each of the two cell lines shCtrl and shAtg7 BV2 in unstimulated condition. b Volcano plot displaying the fold change in log2 plotted against the FDR in negative log10 in untreated condition. Blue dots represent less expressed genes in shAtg7 BV2 cells with a total fold change of maximally - 2, red dots represent genes that are higher expressed in shAtg7 BV2 cells with a total fold change of at least 2, respectively. Differential gene expression analysis revealed a total of 469 genes higher expressed, and 574 lower expressed in shAtg7 BV2 compared to shCtrl BV2 at baseline. Graphs show the 50 genes with the lowest (c) fold change and the highest (d) fold change in shAtg7 cells compared to shCtrl BV2 in untreated condition. Atg7 is highlighted in orange with a negative log2 fold change of 1.724

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Molecular Brain

ISSN: 1756-6606