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Fig. 4 | Molecular Brain

Fig. 4

From: Atg7 deficiency in microglia drives an altered transcriptomic profile associated with an impaired neuroinflammatory response

Fig. 4

Gene Ontology network analysis reveals reduced expression of immune response-related genes in Atg7-deficient microglia. a, b Network analysis of enriched GO term clusters generated from differentially expressed genes with significant FDR (< 0.05). Nodes represent GO terms, clusters are nodes grouped based on similarity. Node size corresponds to number of genes. Node color corresponds to the significance of correlation, where the darker the color is, the smaller the FDR values gets. Lines represent the number of genes overlapping between nodes. Less expressed genes (a) versus more expressed (b) in shAtg7 BV2 as compared to shCtrl BV2 at baseline. c–e Graphs show the top 30 genes represented in the GO term clusters: c C2 cytokine production and cytokine-mediated signaling pathway; d C6 immune response and e C1 protein modification related genes (additional information about the clusters are available in Additional file 4)

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Molecular Brain

ISSN: 1756-6606