Skip to main content
Fig. 6 | Molecular Brain

Fig. 6

From: Atg7 deficiency in microglia drives an altered transcriptomic profile associated with an impaired neuroinflammatory response

Fig. 6

Microglial Atg7 deficiency is associated with reduced NF-κB-dependent signaling. a TRRUST analysis, which allows the identification of transcription factor potentially involved in cell response based on the expression of their target genes, revealed NFKB1 as transcription factor candidate negatively affected by the microglial Atg7 knockdown. Input genes used exhibited lower expression in shAtg7 as compared to shCtrl BV2 (FC < 1.5 and FDR < 0.05), significance of association is shown with the respective p value. b, c similar TRRUST-based analyses performed at 3 h (b) and 6 h (c) post LPS-treatment likewise indicated a significant negative impact on the transcriptional activity of NFKB1 at 6 h post LPS in shAtg7 BV2 cells as compared to shCtrl BV2 cells

Back to article page

Molecular Brain

ISSN: 1756-6606