Table 1 Proteins involved in mitochondrial pathways affected in Ts1Cje SNs
Symbol | Entrez gene name | ID | Ts1Cje | Pathway |
|---|---|---|---|---|
APP | Amyloid beta precursor protein | P12023 | 1.246 | Mitochondrial dysfunction Sirtuin signaling |
ATP5MF | ATP synthase membrane subunit f | P56135 | 1.925 | Mitochondrial dysfunction Oxidative phosphorylation |
ATP5PD | ATP synthase peripheral stalk subunit d | Q9DCX2 | 1.523 | Mitochondrial dysfunction Oxidative phosphorylation |
ATP5PF | ATP synthase peripheral stalk subunit F6 | P97450 | 1.907 | Mitochondrial dysfunction Oxidative phosphorylation Sirtuin signaling |
COX4I1 | Cytochrome c oxidase subunit 4I1 | P19783 | 1.818 | Mitochondrial dysfunction Oxidative phosphorylation |
COX5A | Cytochrome c oxidase subunit 5A | P12787 | 1.889 | Mitochondrial dysfunction Oxidative phosphorylation |
Cox6c | Cytochrome c oxidase subunit 6C | Q9CPQ1 | 2.119 | Mitochondrial dysfunction Oxidative phosphorylation |
CYC1 | Cytochrome c1 | Q9D0M3 | 1.728 | Mitochondrial dysfunction Oxidative phosphorylation Sirtuin signaling |
CYCS | Cytochrome c. somatic | P62897 | 1.976 | Mitochondrial dysfunction Oxidative phosphorylation |
GPD2 | Glycerol-3-phosphate dehydrogenase 2 | Q64521 | 1.549 | Mitochondrial dysfunction |
MAOB | Monoamine oxidase B | Q8BW75 | 1.235 | Mitochondrial dysfunction |
MT-CO2 | Cytochrome c oxidase subunit II | P00405 | 2.804 | Mitochondrial dysfunction Oxidative phosphorylation |
NDUFA2 | NADH:ubiquinone oxidoreductase subunit A2 | Q9CQ75 | 1.337 | Mitochondrial dysfunction Oxidative phosphorylation Sirtuin signaling |
NDUFA4 | NDUFA4 mitochondrial complex associated | Q62425 | 1.331 | Mitochondrial dysfunction Oxidative phosphorylation Sirtuin signaling |
NDUFA8 | NADH:ubiquinone oxidoreductase subunit A8 | Q9DCJ5 | 1.546 | Mitochondrial dysfunction Oxidative phosphorylation Sirtuin signaling |
NDUFAF1 | NADH:ubiquinone oxidoreductase complex assembly factor 1 | A2AQ17 | 1.359 | Mitochondrial dysfunction Sirtuin signaling |
NDUFS1 | NADH:ubiquinone oxidoreductase core subunit S1 | Q91VD9 | 1.813 | Mitochondrial dysfunction Oxidative phosphorylation Sirtuin signaling |
NDUFS3 | NADH:ubiquinone oxidoreductase core subunit S3 | Q9DCT2 | 1.713 | Mitochondrial dysfunction Oxidative phosphorylation Sirtuin signaling |
NDUFS6 | NADH:ubiquinone oxidoreductase subunit S6 | P52503 | 1.368 | Mitochondrial dysfunction Oxidative phosphorylation Sirtuin signaling |
NDUFV2 | NADH:ubiquinone oxidoreductase core subunit V2 | Q9D6J6 | 1.487 | Mitochondrial dysfunction Oxidative phosphorylation Sirtuin signaling |
SLC25A4 | Solute carrier family 25 member 4 | P48962 | 1.591 | Sirtuin signaling |
UQCRB | Ubiquinol-cytochrome c reductase binding protein | Q9CQB4 | 1.928 | Mitochondrial dysfunction Oxidative phosphorylation |
UQCRC1 | Ubiquinol-cytochrome c reductase core protein 1 | Q9CZ13 | 1.687 | Mitochondrial dysfunction Oxidative phosphorylation |
UQCRFS1 | Ubiquinol-cytochrome c reductase. Rieske iron-sulfur polypeptide 1 | Q9CR68 | 3.192 | Mitochondrial dysfunction Oxidative phosphorylation Sirtuin signaling |
UQCRQ | Ubiquinol-cytochrome c reductase complex III subunit VII | Q9CQ69 | 2.522 | Mitochondrial dysfunction Oxidative phosphorylation |
VDAC1 | Voltage dependent anion channel 1 | Q60932 | 1.762 | Mitochondrial dysfunction Sirtuin signaling |
VDAC2 | Voltage dependent anion channel 2 | Q60930 | 2.043 | Mitochondrial dysfunction Sirtuin signaling |
WRN | Werner syndrome RecQ like helicase | O09053 | − 1.341 | Sirtuin signaling |