Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down’s syndrome mouse model

Table 3 Dendritic spine morphology comparison

Spine morphology	WT (n = 248)	Ts1Cje (n = 151)	WT RAPA (n = 143)	Ts1Cje RAPA (n = 635)
Filopodium	14.9	13.2	22.4	19.7
Stubby	27.8	29.8	25.2	26.5
Mushroom	57.3	57.0	52.4	53.9

The percentages of filopodia, stubby and mushroom spines present in secondary dendrites of apical stratum radiatum CA1 neurons in WT, Ts1Cje, and prenatally rapamycin-treated WT and Ts1Cje mice are indicated. Number of mice used per condition was 2, except for WT RAPA (a single animal). Total number of spines (n) is also indicated for each experimental group

ISSN: 1756-6606