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Fig. 4 | Molecular Brain

Fig. 4

From: APOE genotype dependent molecular abnormalities in the cerebrovasculature of Alzheimer’s disease and age-matched non-demented brains

Fig. 4

Canonical pathways modulated in the cerebrovasculature of the inferior frontal gyrus in healthy controls with different  APOE genotypes cases. Identified canonical pathways were generated from the list of significantly modulated proteins between healthy controls from APOE2/E2 vs APOE3/E3, APOE3/E4 vs APOE3/E3, and APOE4/E4 vs APOE3/E3 genotypes using Ingenuity pathway analyses. Values represent negative log 10 of FDR adjusted P value after Fischer’s test and Benjamin Hochberg correction. Significant cut-off is set at \(\ge\) 2. APOE2/E2 vs APOE3/E3 (45 pathways identified), APOE4/E4 vs APOE3/E3 (25 pathways identified), and APOE3/E4 vs APOE3/E3 (7 pathways identified)

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Molecular Brain

ISSN: 1756-6606