Fig. 6

Differentially expressed proteins and cell type origin in the cerebrovasculature of the inferior frontal gyrus between Alzheimer's disease (AD) patients and controls from different APOE genotype backgrounds. Heat map (Log2FC) of all master proteins identified between AD vs controls cases across the four different APOE genotypes (A). Volcano plot of differentially expressed proteins in AD vs matched controls from APOE2/E3 (B), APOE3/E3 (C), APOE3/E4 (D), and APOE4/E4 (E) genotypes. Pie chart inset of graphs shows up/down-regulated proteins from each comparisons. Pie Chart shows origin of cell types where significant (cerebrovascular cell specific) proteins are observed from the comparisons between AD vs control cases from APOE2/E3 (b), APOE3/E3 (c), APOE3/E4 (d), and APOE4E/4 (e) genotypes. Values are generated from the ratio of significantly altered cerebrovascular cell specific proteins identified within our AD vs control datasets, and expressed as a percentage of all 4 cerebrovascular cell types. . EnD—endothelial cells, Ast—astrocytes, Per—Pericytes, SMC—smooth muscle cells. (F) shows heat map of the top 3 pathways for the four different genotype comparisons and the corresponding number of significant proteins and their Log2 fold change expression level