Table 4 List of Top 25 proteins significantly regulated in the cerebrovasculature of the inferior frontal gyrus in Alzheimer's disease vs controls from APOE3/4 genotype
Gene ID | Label | Protein name | Biological function | log 2FC | P value |
|---|---|---|---|---|---|
AINX | Q16352 | Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) | Structural constituent of cytoskeleton | 0.845 | 3.38E−05 |
MYH9 | P35579 | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) | Actin binding | − 0.593 | 5.01E−05 |
Q59GY2 | Q9HBB3 | 60S ribosomal protein L6 | Structural constituent of ribosome | − 0.569 | 6.24E−05 |
B2R8Z8 | Q59GY2 | Ribosomal protein L4 variant (Fragment) | RNA binding | − 0.558 | 1.23E−04 |
A0A024R333 | B5BUB1 | RuvB-like helicase (EC 3.6.4.12) (Fragment) | Chromatin binding | − 0.438 | 1.26E−04 |
ERP29 | B2R8Z8 | cDNA, FLJ94136, synaptotagmin binding, cytoplasmic RNA interacting protein (SYNCRIP) | Chaperone binding | − 0.663 | 2.19E−04 |
RS2 | A0A024R333 | Transmembrane protein 113, isoform CRA_a | Cadherin binding | − 0.344 | 4.49E−04 |
Q6FGH9 | P30040 | Endoplasmic reticulum resident protein 29 (ERp29) (Endoplasmic reticulum resident protein 28) | Dynein intermediate chain binding | − 0.985 | 5.07E−04 |
RS16 | P15880 | 40S ribosomal protein S2 (40S ribosomal protein S4) | RNA binding | − 0.662 | 5.51E−04 |
SRSF7 | Q6FGH9 | Dynein light chain | Protein domain specific binding | − 0.465 | 5.64E−04 |
A0A0S2Z3L2 | P62249 | 40S ribosomal protein S16 (Small ribosomal subunit protein uS9) | ATP binding | − 0.611 | 6.75E−04 |
Q53F64 | Q16629 | Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7) | RNA binding | − 0.742 | 7.52E−04 |
V9HWK4 | A0A0S2Z3L2 | ATPase Ca++ transporting cardiac muscle slow twitch 2 isoform 1 | Double-stranded RNA binding | − 0.331 | 1.02E−03 |
A8KAP3 | Q14498 | RNA-binding protein 39 (CAPER alpha) (Hepatocellular carcinoma protein 1) | GTPase activity | − 0.396 | 1.03E−03 |
A8K329 | A0A024R1Q8 | Ribosomal protein L23, isoform CRA_b | RNA binding | − 0.488 | 1.09E−03 |
NFL | Q53F64 | Heterogeneous nuclear ribonucleoprotein AB isoform a variant (Fragment) | Structural constituent of cytoskeleton | − 0.686 | 1.10E−03 |
CAVN1 | V9HWK4 | Epididymis luminal protein 162 | Identical protein binding | − 0.547 | 1.11E-03 |
J3KTL2 | Q13435 | Splicing factor 3B subunit 2 | Protein kinase B binding | − 0.644 | 1.23E−03 |
ACTN4 | A8KAP3 | cDNA FLJ78483, elongation factor Tu GTP binding domain containing 2 (EFTUD2) | Actin filament binding | − 0.429 | 1.66E−03 |
RL24 | A8K329 | cDNA FLJ76656, scaffold attachment factor B (SAFB) | Cadherin binding | − 0.662 | 1.67E−03 |
OGT1 | P07196 | Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) | Phosphatidylinositol-3,4,5-trisphosphate binding | 1.164 | 1.86E−03 |
B1PS43 | Q6NZI2 | Caveolae-associated protein 1 (Cavin-1) | Actin filament binding | − 0.463 | 1.94E−03 |
RL3 | J3KTL2 | Serine/arginine-rich-splicing factor 1 | Structural constituent of ribosome | − 0.711 | 1.98E−03 |
B4DEG4 | O43707 | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | RNA binding | − 0.495 | 2.02E−03 |
PLEC | A0A0A6YYL6 | Protein RPL17-C18orf32 | Structural constituent of cytoskeleton | − 0.565 | 2.23E−03 |