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Table 4 List of Top 25 proteins significantly regulated in the cerebrovasculature of the inferior frontal gyrus in Alzheimer's disease vs controls from APOE3/4 genotype

From: APOE genotype dependent molecular abnormalities in the cerebrovasculature of Alzheimer’s disease and age-matched non-demented brains

Gene ID Label Protein name Biological function log 2FC P value
AINX Q16352 Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) Structural constituent of cytoskeleton 0.845 3.38E−05
MYH9 P35579 Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) Actin binding − 0.593 5.01E−05
Q59GY2 Q9HBB3 60S ribosomal protein L6 Structural constituent of ribosome − 0.569 6.24E−05
B2R8Z8 Q59GY2 Ribosomal protein L4 variant (Fragment) RNA binding − 0.558 1.23E−04
A0A024R333 B5BUB1 RuvB-like helicase (EC 3.6.4.12) (Fragment) Chromatin binding − 0.438 1.26E−04
ERP29 B2R8Z8 cDNA, FLJ94136, synaptotagmin binding, cytoplasmic RNA interacting protein (SYNCRIP) Chaperone binding − 0.663 2.19E−04
RS2 A0A024R333 Transmembrane protein 113, isoform CRA_a Cadherin binding − 0.344 4.49E−04
Q6FGH9 P30040 Endoplasmic reticulum resident protein 29 (ERp29) (Endoplasmic reticulum resident protein 28) Dynein intermediate chain binding − 0.985 5.07E−04
RS16 P15880 40S ribosomal protein S2 (40S ribosomal protein S4) RNA binding − 0.662 5.51E−04
SRSF7 Q6FGH9 Dynein light chain Protein domain specific binding − 0.465 5.64E−04
A0A0S2Z3L2 P62249 40S ribosomal protein S16 (Small ribosomal subunit protein uS9) ATP binding − 0.611 6.75E−04
Q53F64 Q16629 Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7) RNA binding − 0.742 7.52E−04
V9HWK4 A0A0S2Z3L2 ATPase Ca++ transporting cardiac muscle slow twitch 2 isoform 1 Double-stranded RNA binding − 0.331 1.02E−03
A8KAP3 Q14498 RNA-binding protein 39 (CAPER alpha) (Hepatocellular carcinoma protein 1) GTPase activity − 0.396 1.03E−03
A8K329 A0A024R1Q8 Ribosomal protein L23, isoform CRA_b RNA binding − 0.488 1.09E−03
NFL Q53F64 Heterogeneous nuclear ribonucleoprotein AB isoform a variant (Fragment) Structural constituent of cytoskeleton − 0.686 1.10E−03
CAVN1 V9HWK4 Epididymis luminal protein 162 Identical protein binding − 0.547 1.11E-03
J3KTL2 Q13435 Splicing factor 3B subunit 2 Protein kinase B binding − 0.644 1.23E−03
ACTN4 A8KAP3 cDNA FLJ78483, elongation factor Tu GTP binding domain containing 2 (EFTUD2) Actin filament binding − 0.429 1.66E−03
RL24 A8K329 cDNA FLJ76656, scaffold attachment factor B (SAFB) Cadherin binding − 0.662 1.67E−03
OGT1 P07196 Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) Phosphatidylinositol-3,4,5-trisphosphate binding 1.164 1.86E−03
B1PS43 Q6NZI2 Caveolae-associated protein 1 (Cavin-1) Actin filament binding − 0.463 1.94E−03
RL3 J3KTL2 Serine/arginine-rich-splicing factor 1 Structural constituent of ribosome − 0.711 1.98E−03
B4DEG4 O43707 Alpha-actinin-4 (Non-muscle alpha-actinin 4) RNA binding − 0.495 2.02E−03
PLEC A0A0A6YYL6 Protein RPL17-C18orf32 Structural constituent of cytoskeleton − 0.565 2.23E−03
  1. Tables show the biological functions of the top 25 significant proteins between AD vs control from the APOE3/E4 genotype