Fig. 1
From: Reductions in midbrain GABAergic and dopamine neuron markers are linked in schizophrenia
Gene (GAD1) and protein (GAD65/67) expression levels of glutamate decarboxylase (GAD) in the midbrain in schizophrenia. a GAD1 mRNA was 30.96% lower in schizophrenia cases relative to controls, and this was not exacerbated by inflammatory status. b GAD65/67 protein was 34.14% lower in schizophrenia cases compared to controls, and this was also independent of inflammatory status. Pink dots are low inflammatory/schizophrenia cases, dark red dots are high inflammatory/schizophrenia cases. c A GAD65/67 protein band (~ 66 kDa) was detected in all control and schizophrenia cases. β-actin (42 kDa) was used as a loading control. IC internal control, C control, SH schizophrenia high inflammatory, SL schizophrenia low inflammatory. & inflammatory status unknown. Statistical results for analysis by inflammatory subgroup are in Table 3. Bars indicate mean ± SEM. *p < 0.05, ****p < 0.0001