Table 2 Demographic details of the post-mortem midbrain mRNA and protein cohorts classified by inflammatory subgroup. Table previously published in [54]

Age (years) (range)

50.54 (22–67)

48.27 (30–64)

54.92 (26–67)

H(2) = 2.81, p = 0.25

51.19 (22–67)

49.31 (30–64)

56.17 (26–67)

H(2) = 2.89, p = 0.24

Sex (M,F)

(20,8)

(11,4)

(8,5)

χ²(2,56) = 0.543, p = 0.762

(19,7)

(9,4)

(7,5)

χ²(2,51) = 0.832, p = 0.660

pH

6.66 ± 0.26

6.52 ± 0.20

6.49 ± 0.20

H(2) = 8.51, p = 0.014*

6.69 ± 0.22

6.54 ± 0.20

6.52 ± 0.18

F(2,48) = 4.02, p = 0.024*

PMI (hours) (range)

31.68 ± 10.21 (15–50)

33.43 ± 14.66 (18–64)

38.23 ± 21.01 (5–72)

F(2,53) = 0.91, p = 0.41

33.42 ± 10.21 (15–50)

35.19 ± 14.93 (18–64)

39.62 ± 21.30 (5–72)

F(2,48) = 1.00, p = 0.38

RIN (range)

5.56 ± 1.15 (3.0–7.3)

5.53 ± 1.28 (3.3–7.2)

5.70 ± 1.39 (3.2–8.3)

F(2,53) = 0.079, p = 0.92

–

–

–

–

Duration of illness

–

26.43 ± 11.65

31.62 ± 13.926

t(26) = − 1.073, p = 0.293

–

25.92 ± 11.30

32.33 ± 14.29

t(22) = − 1.220, p = 0.24

Daily CPZ (mg)

–

483.54 ± 177.63

1039.93 ± 637.06

t(10.169) = 2.68, p = 0.023*

–

422.30 ± 116.23

1043.11 ± 675.69

U = 81.0, p = 0.002***

Last recorded CPZ (mg)

–

361.53 ± 316.56

869.85 ± 538.82

U = 156.5, p = 0.005**

–

391.00 ± 331.35

860.17 ± 561.60

U = 210.5, p = 0.019*

Lifetime CPZ (g)

–

4204.952 ± 2170.41

13,063.22 ± 11,129.88

U = 100.0, p = 0.007**

–

3799.83 ± 1800.43

13,570.25 ± 11,681.88

U = 77.0, p = 0.008**