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Fig. 7 | Molecular Brain

Fig. 7

From: Electroacupuncture improves repeated social defeat stress-elicited social avoidance and anxiety-like behaviors by reducing Lipocalin-2 in the hippocampus

Fig. 7

EA stimulation at the Baihui (GV 20) and Dazhui (GV 14) acupoints down-regulates the expression of lipocalin 2 in reactive astrocytes in RSDS-treated mice. Double-labeling immunofluorescence of lipocalin 2 (green) and GFAP (red) in the control (a–e), RSDS (f–j) and RSDS-treated mice with EA stimulation (k–o) in the ventral hippocampus of the brain sections. DAPI staining (blue) was used to label the nuclei. The merged yellow images indicate co-localization of lipocalin 2 and GFAP (white arrowheads). (3 animals in each group) All images were taken at a primary magnification of 200 × , and the high magnification (1000×) of d, i and n are shown in e, j, and o, respectively. EA: electroacupuncture, RSDS: repeated social defeat stress, GFAP: glial fibrillary acidic protein, LCN2: lipocalin 2

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Molecular Brain

ISSN: 1756-6606