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Table 1 βarrestin2 recruitment to ACKR3-Venus in HEK-293 cells

From: Ackr3-Venus knock-in mouse lights up brain vasculature

Compound

Emax (%)

LogEC50

CXCL12

100.0 ± 5.6

− 9.15 ± 0.15

VUF11207

73.8 ± 5.6

− 7.78 ± 0.18

TC14012

63.6 ± 4.6

− 6.97 ± 0.14

AMD3100

55.2 ± 6.2

− 7.02 ± 0.23

  1. Cells were exposed for 10 min to increasing concentrations of the indicated compound. Emax values are expressed as % of the maximal response induced by CXCL12. Potency is expressed as LogEC50. Data are the Mean ± SEM of 3–5 independent experiments (Fig. 2B)
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Molecular Brain

ISSN: 1756-6606