Fig. 6

Changes of representative metabolites in the most perturbed metabolic pathways. Each metabolite was presented with p-value < 0.05, fold change ≥|1. 2|, and high importance on each pathway in PPC. The fold change and statistical significance of each metabolite for FC vs. Con in PPC, AMG, and HPC were presented (Con-PPC, n = 16 mice; FC-PPC, n = 17 mice; Con-AMG, n = 16 mice; FC-AMG, n = 17 mice; Con-HPC, n = 16 mice; FC-HPC, n = 13 mice). Two-tailed unpaired t-test, data are mean ± SEM; *p < 0.05, **p < 0.01, ***p < 0.001. N.D. not determined. PPanSH 4′-Phosphopantetheine, ADPR ADP-ribose, ADPRP ADP-ribose 2′-phosphate, cADPR cyclic ADP-ribose