Fig. 4

LTP recorded from slices of saline-treated, MPTP-treated 3d, and MPTP-treated 14d mice by extracellular field potential recording respectively. a Schematic diagram and the microphotograph showed the scale of the MED-64 probe (electrode size is 50 × 50 μm, interpolar distance of electrodes is 150 μm). b One example location of MED-64 probe on the ACC slice (left) and microscopy photograph of the location of ACC slice and MED-64 probe (right). Spatial distribution of extracellular field potential induced by electrical stimulation (marked as red circle) in layers V of the ACC slices from saline-treated (c), MPTP-treated 3d (e) and MPTP-treated 14d mice (g). The temporal changes of the fEPSP slopes of all traces (top) and averaged slope (bottom) of three ACC slices from saline-treated (d), MPTP-treated 3d (f) and MPTP-treated 14d mice (h). i All channels with L-LTP (top), E-LTP (middle) and none-LTP (bottom) were induced in saline-treated (left), MPTP-treated 3d (middle), and MPTP-treated 14d mice (right) (saline: 11 slices/7 mice; MPTP 3d: 12 slices/8 mice; MPTP 14d: 10 slices/7 mice). j The temporal changes of the averaged fEPSP slopes of all slices from saline-treated, MPTP-treated 3d, and MPTP-treated 14d mice. k MPTP-treated group showed reduced averaged fEPSP slope of all activated channels, but not all channels with LTP. l MPTP-treated 3d group showed reduced averaged number of LTP channels and increased none-LTP channels than saline-treated group or MPTP-treated 14d group. **p < 0.01, MPTP 3d vs saline. ##p < 0.01, MPTP 3d vs MPTP 14d