Table 1 Behavior test results of motor function, pain, and anxiety-related behavior in A53T transgenic, MPTP, and 6-OHDA mice models used for the study of Parkinson’s disease

Motor function tests

Grip strength (kg)

0.22 ± 0.01

0.20 ± 0.01

N.S

0.20 ± 0.01

0.16 ± 0.004

↓**

0.20 ± 0.008

0.17 ± 0.007

↓**

RotaRod (min)

4.34 ± 0.45

3.47 ± 0.40

N.S

3.90 ± 0.39

2.03 ± 0.24

↓**

4.06 ± 0.37

3.11 ± 0.33

↓**

Open field

-Total distance (m)

74.32 ± 4.10

80.88 ± 8.46

N.S

79.22 ± 9.23

51.66 ± 7.41

↓**

73.63 ± 6.46

47.23 ± 4.10

↓**

AI homecage

-Hanging time (min)

14.56 ± 2.63

10.41 ± 2.02

↓**

13.66 ± 1.54

9.11 ± 1.38

↓**

12.72 ± 1.56

9.54 ± 0.90

↓**

AI homecage

-Standing time (min)

10.82 ± 3.37

12.80 ± 4.14

N.S

10.46 ± 2.54

7.01 ± 3.22

↓**

10.07 ± 2.02

6.48 ± 3.11

↓**

AI homecage

-Activity time (%)

39.65 ± 6.20

42.37 ± 4.58

N.S

38.69 ± 3.30

15.36 ± 5.73

↓**

36.69 ± 2.37

35.36 ± 4.89

N.S

Pain behavior tests

Tail flick (s)

5.60 ± 0.37

5.00 ± 0.51

N.S

6.02 ± 0.26

4.23 ± 0.19

↓**

5.54 ± 0.46

4.20 ± 0.12

↓**

Hot plate (s)

12.04 ± 1.09

10.09 ± 0.65

↓**

12.48 ± 0.96

10.08 ± 0.46

↓**

11.56 ± 0.81

10.10 ± 0.84

N.S

Mechanical

threshold (g)

0.73 ± 0.15

0.49 ± 0.11

↓**

0.84 ± 0.14

0.28 ± 0.05

↓**

0.76 ± 0.18

0.37 ± 0.10

↓**

Mechanical

allodynia (%)

5.00 ± 4.14

35.00 ± 9.69

↑**

3.5 ± 6.31

47.5 ± 12.08

↑**

6.67 ± 3.40

40.00 ± 18.76

↑**

Anxiety -related behavior tests

Open field

-Time in central zone (%)

11.34 ± 3.20

13.64 ± 2.58

N.S

12.94 ± 2.30

4.27 ± 0.73

↓**

11.67 ± 2.37

4.35 ± 1.89

↓**

Elevated plus maze

-Time in open arms (%)

10.40 ± 2.09

11.94 ± 1.65

N.S

11.89 ± 0.86

4.59 ± 0.66

↓**

9.67 ± 0.81

5.7 ± 0.64

↓**

Elevated plus maze

-Number of entries

16.25 ± 4.20

14.65 ± 4.58

N.S

15.64 ± 3.30

12.96 ± 6.73

N.S

13.37 ± 2.37

11.38 ± 4.89

N.S