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Table 1 Behavior test results of motor function, pain, and anxiety-related behavior in A53T transgenic, MPTP, and 6-OHDA mice models used for the study of Parkinson’s disease

From: Synaptic potentiation of anterior cingulate cortex contributes to chronic pain of Parkinson’s disease

Behavior tests A53T
transgenic model
MPTP
model
6-OHDA
model
WT
A53T
Saline
MPTP
Saline
6-OHDA
Motor function tests Grip strength (kg) 0.22 ± 0.01
0.20 ± 0.01
N.S 0.20 ± 0.01
0.16 ± 0.004
↓** 0.20 ± 0.008
0.17 ± 0.007
↓**
  RotaRod (min) 4.34 ± 0.45
3.47 ± 0.40
N.S 3.90 ± 0.39
2.03 ± 0.24
↓** 4.06 ± 0.37
3.11 ± 0.33
↓**
  Open field
-Total distance (m)
74.32 ± 4.10
80.88 ± 8.46
N.S 79.22 ± 9.23
51.66 ± 7.41
↓** 73.63 ± 6.46
47.23 ± 4.10
↓**
  AI homecage
-Hanging time (min)
14.56 ± 2.63
10.41 ± 2.02
↓** 13.66 ± 1.54
9.11 ± 1.38
↓** 12.72 ± 1.56
9.54 ± 0.90
↓**
  AI homecage
-Standing time (min)
10.82 ± 3.37
12.80 ± 4.14
N.S 10.46 ± 2.54
7.01 ± 3.22
↓** 10.07 ± 2.02
6.48 ± 3.11
↓**
  AI homecage
-Activity time (%)
39.65 ± 6.20
42.37 ± 4.58
N.S 38.69 ± 3.30
15.36 ± 5.73
↓** 36.69 ± 2.37
35.36 ± 4.89
N.S
Pain behavior tests Tail flick (s) 5.60 ± 0.37
5.00 ± 0.51
N.S 6.02 ± 0.26
4.23 ± 0.19
↓** 5.54 ± 0.46
4.20 ± 0.12
↓**
Hot plate (s) 12.04 ± 1.09
10.09 ± 0.65
↓** 12.48 ± 0.96
10.08 ± 0.46
↓** 11.56 ± 0.81
10.10 ± 0.84
N.S
Mechanical
threshold (g)
0.73 ± 0.15
0.49 ± 0.11
↓** 0.84 ± 0.14
0.28 ± 0.05
↓** 0.76 ± 0.18
0.37 ± 0.10
↓**
Mechanical
allodynia (%)
5.00 ± 4.14
35.00 ± 9.69
↑** 3.5 ± 6.31
47.5 ± 12.08
↑** 6.67 ± 3.40
40.00 ± 18.76
↑**
Anxiety -related behavior tests Open field
-Time in central zone (%)
11.34 ± 3.20
13.64 ± 2.58
N.S 12.94 ± 2.30
4.27 ± 0.73
↓** 11.67 ± 2.37
4.35 ± 1.89
↓**
Elevated plus maze
-Time in open arms (%)
10.40 ± 2.09
11.94 ± 1.65
N.S 11.89 ± 0.86
4.59 ± 0.66
↓** 9.67 ± 0.81
5.7 ± 0.64
↓**
Elevated plus maze
-Number of entries
16.25 ± 4.20
14.65 ± 4.58
N.S 15.64 ± 3.30
12.96 ± 6.73
N.S 13.37 ± 2.37
11.38 ± 4.89
N.S
  1. N.S.: not significant, ↓: decreased, ↑: increased
  2. **p < 0.01