Fig. 4
The expression of three individual L1 loci was significantly lower in individuals with ALS or ALSND. a The expression of the intact L1 at chr7:111,243,515–111,249,546 in the intron of the IMMPL2 gene was significantly lower (padj = 0.012) in the motor cortex of individuals with ALS or ALSND compared to controls. b The expression of the intact L1 at chr4:136,293,494–136,299,546 was significantly lower (padj = 0.035) in the motor cortex of individuals with ALS or ALSND compared to controls. c The expression of the non-intact L1 at chr8:88,685,705–88,691,760 was significantly lower (padj = 0.013) in the frontal cortex of individuals with ALS or ALSND compared to controls. Wilcoxon test with Benjamini–Hochberg adjustment *p < 0.05, MCX motor cortex, FCX frontal cortex, ALS amyotrophic lateral sclerosis, ALSND amyotrophic lateral sclerosis and other neurological disorder, NNC non-neurological control, FPM fragments per million