Table 2 Concentration of neuroglial proteins in selected CNS regions
From: Distribution of five clinically important neuroglial proteins in the human brain
CNS region | GFAP (µg/g) | MBPa (µg/g) | NFLa (µg/g) | Tau (µg/g) | UCHL1 (µg/g) | Total protein (mg/g) |
|---|---|---|---|---|---|---|
Cerebrum | ||||||
Cortex | ||||||
Frontal | 4.8 (1.7–13) | 1900 (1500–2500) | 12 (8.6–17) | 190 (160–220) | 160 (110–230) | 43 (40–46) |
Parietal | 5.2 (1.7–16) | 2100 (1600–2800) | 14 (10–18) | 210 (170–270) | 150 (110–220) | 44 (40–48) |
Temporal | 5.4 (2.0–15) | 1700 (1100–2600) | 12 (9.1–17) | 200 (180–230) | 160 (96–250) | 46 (44–49) |
Occipital | 4.6 (1.3–16) | 2300 (1700–3100) | 13 (8.9–18) | 190 (150–240) | 130 (76–210) | 42 (39–45) |
White matter | ||||||
Frontal | 5.9 (2.0–17) | 16,000 (12,000–20,000) | 10 (5.4–19) | 94 (73–120) | 110 (94–130) | 32 (29–36) |
Parietal | 5.0 (1.6–16) | 20,000 (14,000–29,000) | 17 (9.9–30) | 71 (56–89) | 100 (89–120) | 31 (28–35) |
Temporal | 14 (3.7–55) | 21,000 (16,000–26,000) | 27 (15–50) | 64 (47–86) | 100 (94–120) | 34 (31–38) |
Occipital | 20 (5.2–79) | 21,000 (17,000–27,000) | 30 (17–54) | 46 (37–59) | 95 (79–110) | 33 (30–37) |
Caudate nucleus | 31 (11–82) | 3200 (2700–3900) | 13 (7.3–23) | 160 (150–180) | 140 (60–310) | 47 (42–52) |
Internal capsule | 5.9 (1.9–19) | 11,000 (7400–16,000) | 27 (12–60) | 120 (88–170) | 150 (94–250) | 44 (39–49) |
Hippocampus | 91 (51–160) | 7600 (6000–9500)b | 47 (18–120)b | 110 (79–150) | 190 (110–310) | 49 (45–54) |
Diencephalon | ||||||
Thalamus | 7.6 (2.4–24) | 13,000 (7900–21,000) | 38 (20–72) | 83 (64–110) | 150 (72–310) | 44 (39–50) |
Brainstem | ||||||
Mesencephalon | 46 (21–98) | 13,000 (7100–23,000) | 33 (20–56) | 62 (45–85) | 130 (94–180) | 36 (30–42) |
Pons | 25 (9.0–69) | 19,000 (13,000–30,000) | 26 (18–38) | 62 (49–77) | 160 (120–220) | 38 (34–43) |
Medulla oblongata | 100 (61–170) | 18,000 (13,000–25,000) | 17 (11–25) | 42 (39–46) | 130 (100–170) | 37 (32–42) |
Cervical spinal cord | 110 (60–220) | 21,000 (15,000–30,000) | 30 (20–45) | 17 (14–22) | 140 (120–160) | 37 (34–41) |
Cerebellum | 19 (9.4–38) | 2000 (1500–2600) | 7.3 (4.8–11) | 49 (39–61) | 72 (48–110) | 45 (42–49) |