Fig. 3

Altered circadian wheel-running activity correlates with the loss of CDK5 in the DS in mice. A Representative actograms showing wheel-running activity during entrainment in a 12/12 h light/dark (LD) cycle, in which gray shading represents the dark periods. B Representative actograms showing wheel-running activity under a 12:12 dark/dark (DD) cycle, in which gray shading represents the periods of the subjective night. Note one line represent running duration from an exercised mouse in 48 h, and data were obtained from four animals per group. C Activity counts, activity durations, and α/ρ ratio in a 12:12 night/day cycle under LD conditions for WT, DS-CDK5-NC, and DS-CDK5-KD mice. D Activity counts, activity durations, and α/ρ ratio in a 12:12 night/day cycle under DD conditions for WT, DS-CDK5-NC, and DS-CDK5-KD mice. Data are represented as the mean ± SEM, n = 12 mice per group. One-way ANOVA, Tukey’s multiple comparisons test, *p < 0.05, **p < 0.01, ***p < 0.001 vs WT