Skip to main content
Fig. 4 | Molecular Brain

Fig. 4

From: mTORC1 function in hippocampal parvalbumin interneurons: regulation of firing and long-term potentiation of intrinsic excitability but not long-term contextual fear memory and context discrimination

Fig. 4

Conditional knock-out of Rptor in PV interneurons does not affect contextual fear memory or context discrimination. A Diagram of the contextual fear memory and context discrimination protocol. B Percentage of time freezing after each foot shock during the training session for PV-Raptor-WT (n = 21), PV-Raptor-Het (n = 13) and PV-Raptor-Homo (n = 15) mice (Baseline: before the first foot shock), indicating similar anxiety level and sensorimotor gating in the three groups. C Percentage of time freezing during the long-term memory tests at 24 h in the PV-Raptor-WT, PV-Raptor-Het and PV-Raptor-Homo mice (same mice as in B), indicating similar long-term contextual memory in the three groups. D–F Percentage of time freezing during the contextual discrimination test, relative to the training context (D), in the new neutral context (E) and discrimination ratio (F; amount of freezing in [training context]/[training context + neutral context]) for PV-Raptor-WT (n = 12), PV-Raptor-Het (n = 7) and PV-Raptor-Homo (n = 6) mice, indicating similar context discrimination in the three mice groups. **** p < 0.0001, *** p < 0.001, * p < 0.05, ns not significant

Back to article page

Molecular Brain

ISSN: 1756-6606