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Fig. 5 | Molecular Brain

Fig. 5

From: High glucose and palmitic acid induces neuronal senescence by NRSF/REST elevation and the subsequent mTOR-related autophagy suppression

Fig. 5

Knockdown of REST alleviates the senescence-like phenotypes a–d Western blotting image of REST, p16, p21 and γH2A.X at sh-NC and sh-REST. e Immunofluorescence staining of γH2A.X at sh-NC and sh-REST. Scale bar, 25 μm. f SA-β-gal activity at sh-NC and sh-REST. Scale bar, 50 μm. Data are mean ± SD. n = 3 independent experiments for (a), (b), (c), (d) and (e), n = 4 independent experiments for (f). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Unpaired t test for (a), (b), (c), (d), (e) and (f)

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Molecular Brain

ISSN: 1756-6606