Fig. 3

Effects of linopirdine on intrinsic electrophysiological properties at NRs. A Sample traces illustrate action potentials (APs) recorded at a NR in the absence (control, grey) and presence of 100 µM linopirdine (red). Recordings were performed under the whole-cell current-clamp configuration and step currents were injected into the NR through recording electrodes. B–G Bar graphs show, in the absence (control, open bars, n = 10) and presence of linopirdine (red bars, n = 10), intrinsic electrophysiological properties including resting membrane potential (RMP, B), action potential (AP) threshold (C), AP width (D), AP rheobase (E), AP amplitude (F), and membrane input resistance (G). Data represent mean ± SEM, ns, not significantly different, *p < 0.05, **p < 0.01, ***p < 0.001, paired Student’s t-Test