Fig. 2
Expression of TN-associated Cav3.2 variants. a Representative whole-cell T-type current traces recorded in tsA-201 cells expressing Cav3.2 wild-type (WT) in response to 140 ms depolarizing steps to values ranging between − 80 mV and + 20 mV (left panel). Corresponding mean current–voltage relationship (I/V) (right panel) fitted with the modified Boltzmann function (1). b-n Legend same as (a) but for cells expressing TN-associated Cav3.2 variants. The dashed line depicts the I/V curve of the WT channel for comparison. o Corresponding mean maximal macroscopic conductance (Gmax) values obtained from the fit of the I/V curves