Fig. 2

Activation of astrocytes in the DG of Cn mutant mice. Immunostaining images and quantified bar graphs of GFAP (a; left graph: t = 3.84, df = 10, P = 0.0032; right graph: t = 1.93, df = 10, P = 0.083) and Iba1 (b; left graph t = 2.20, df = 9, P = 0.055; right graph t = 0.33, df = 10, P = 0.75). Bar graphs show means ± SEM. Each dot represents one mouse. Scale bars: a left panels 500 μm, right panels 100 μm; b 300 μm. Relative intensity means the ratio of the immunoreactive intensity obtained from the mutants to that of the controls. **P < 0.01, Students t-test