Fig. 5

L-LTP was more easily induced by weak TBS in adult mice than in middle-aged mice. The induction of E-LTP (a) and L-LTP (b) in adult male mice. Summarized plot of the fEPSP slope demonstrates that weak TBS could induce L-LTP in adult male mice (n = 5 slices/5 mice) (c). The induction of E-LTP by weak TBS lasts for at least 2.5 h. Individual data of E-LTP (d) were induced by weak TBS in middle-aged male mice. Summarized plot of the fEPSP slope demonstrates that weak TBS could induce E-LTP in middle-aged male mice (n = 5 slices/5 mice) (e). The induction of E-LTP (f) and L-LTP (g) by weak TBS in adult female mice. Summarized plot of the fEPSP slope demonstrates that weak TBS could induce L-LTP in adult female mice (n = 5 slices/5 mice) (h). Individual data of E-LTP (i) were induced by weak TBS in middle-aged female mice. Summarized plot of the fEPSP slope demonstrates that weak TBS could induce E-LTP in middle-aged female mice (n = 5 slices/5 mice) (j). The bar plots are a quantitative representation of the number of activated channels induced by weak TBS in different ages and genders (k)