Fig. 7

R13 rescued the synaptic tagging in middle-aged mice. Tagging was recorded around site S2 from the brain slices of the R13 treated/untreated middle-aged male mice (a). LTP around S1 was recorded around site S1 from the same brain slices (b). The temporal changes of the average number on sites S1 and S2 of the recruited channels in R13 treated and untreated mice. n = 5 slices from 5 R13 treated mice and n = 4 slices from 5 untreated mice, respectively (c, d). (*p < 0.05, n = 5 mice for each group, Student’s t-test.). The temporal evolving of the 3D surface on site S2 of the R13 untreated mouse brain slice (e). The temporal evolving of the 3D surface on site S2 of the R13 treatment mouse brain slice (f)