Fig. 3

General health and neurological screen of PDZD8-KO mice. a, b Body weight (a) and body temperature (b) of male WT and PDZD8-KO mice at 10 to 20 weeks of age. c Grip strength. d Latency to fall in the wire-hang test. e Latency of the first paw response in the hot-plate test of pain sensitivity. f Latency to fall from the rotating rod in the rotarod test of motor function. All data are means ± s.e.m. (WT mice, n = 18; PDZD8-KO mice, n = 19). P values for differences between genotypes were determined with Student’s t test (a, c), the Mann–Whitney U test (b, d, e), or two-way repeated-measures ANOVA (f). ***P < 0.001; n.s., not significant. The results of all statistical analysis are provided in Additional file 2: Table S2