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Fig. 3 | Molecular Brain

Fig. 3

From: Elucidation of the mechanisms underlying tumor aggravation by the activation of stress-related neurons in the paraventricular nucleus of the hypothalamus

Fig. 3

Effects of the activation of CRHPVN neurons on tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs) in tumor microenvironments. A, B Representative flow cytometric dot plots (left panel) and quantitative analyses of TAM (A), M-MDSC and PMN-MDSC (B) derived from WT/hM3Dq or CRH-Cre/hM3Dq mice. Each point represents the mean ± S.E.M. (n = 6). C, D Quantitative PCR analysis of the expression of various mRNAs in TAM (C) and M-MDSC (D) derived from WT/hM3Dq or CRH-Cre/hM3Dq mice. Each point represents the mean ± S.E.M. Unpaired t-test: *p < 0.05, **p < 0.01 vs. WT/hM3Dq mice (n = 6)

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Molecular Brain

ISSN: 1756-6606