Fig. 3
From: Presenilins regulate synaptic plasticity in the perforant pathways of the hippocampus
Normal spontaneous and miniature EPSCs in PS cDKO mice. a Representative sEPSCs recorded in dentate gyrus granule neurons from control and PS cDKO mice at a holding potential of −80 mV in the presence of blocker of GABAA receptor (100 µM picrotoxin). b Statistical analysis indicates normal sEPSC frequency (p = 0.083, unpaired t-test) and amplitude (p = 0.725, unpaired t-test) in PS cDKO neurons. c Representative mEPSCs recorded in dentate gyrus granule neurons from control and PS cDKO mice at a holding potential of −80 mV in the presence of 100 µM picrotoxin for the blockade of GABAA receptor with 1 µM TTX. d Statistical analysis indicates similar mEPSC frequency (p = 0.967, unpaired t-test) and amplitude (p = 0.216, unpaired t-test) between PS cDKO and control neurons. All data represent mean ± SEM (NS not significant). The number of neurons/mice used in each experiment is shown in parentheses