Fig. 2

LTD-IE affects the AP threshold and amplitude. In representative AP traces, AP thresholds are pointed by red (wild-type) or magenta circle (STIM1^PKO), and red arrows indicate AP amplitudes. A AP threshold of wild-type through time. AP threshold has been gradually decreased. It became significantly lower at the 24 h time point than the sham control (F _{1, 30} = 4.35, p = 0.046). B AP amplitude of wild-type through time. AP amplitude was significantly altered at the 1 h time point compared to sham control and the 4 h time point (sham vs. 1 h, F _{1, 23} = 5.63, p = 0.026; 1 h vs. 4 h, F _{1, 23} = 6.32, p = 0.019). C, D AP thresholds and amplitudes were not significantly altered between the time points. Sample numbers of wild-type (sham n = 15, 1 h n = 10, 4 h n = 15, 24 h n = 17) and STIM1^PKO (sham n = 16, 1 h n = 15, 4 h n = 16, 24 h n = 10) are the same for all panels. Two-way ANOVA test was used for all panels. The graphs are shown as mean ± SEM. *p < 0.05