Fig. 4

Locomotor activity of male and female wild-type and FDNQ175 mice from 6 to 12 months of age. Mean ± SEM average velocity (cm/s) of wild-type (+/+) and heterozygous FDNQ175 (FDNQ175/+) male and female mice at 6 months (n = 14–21 per group) (A), 8 months (n = 12–20 per group) (B), 10 months (n = 12–20 per group) (C), and 12 months (n = 11–19 per group) (D) of age in an open-field arena. (E) Line graph summarizing changes in the mean ± SEM average velocity (cm/s) of wild-type (+/+; n = 19–21) and heterozygous FDNQ175 (FDNQ175/+; n = 14–20) male mice from 6 to 12 months of age tested at 2 month intervals. (F) Line graph summarizing changes in the mean ± SEM average velocity (cm/s) of wild-type (+/+; n = 11–14) and heterozygous FDNQ175 (FDNQ175/+; n = 14–19) female mice from 6 to 12 months of age tested at 2 month intervals. (G) Combined line graph summarizing changes in the mean ± SEM average velocity (cm/s) of wild-type (+/+) and heterozygous FDNQ175 (FDNQ175/+) male and female mice from 6 to 12 months of age tested at 2 month intervals. * indicates significant difference (p < 0.05) between age-matched and sex-matched wild-type (+/+) and heterozygous FDNQ175 (FDNQ175/+) mice. ^# indicates significant difference (p < 0.05) as compared with 6-month-old sex-matched wild-type (+/+) mice. † indicates significant difference (p < 0.05) between age-matched male and female wild-type (+/+) mice. ‡ indicates significant difference (p < 0.05) between age-matched male and female heterozygous FDNQ175 (FDNQ175/+) mice