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Fig. 7 | Molecular Brain

Fig. 7

From: Comparison of Huntington’s disease phenotype progression in male and female heterozygous FDNQ175 mice

Fig. 7

Deposition of mutant huntingtin aggregates increases with age in both male and female FDNQ175 mice. Representative images of staining for mutant huntingtin aggregates using the antibody EM48 (A) and quantification of the number of huntingtin aggregates (B) in striatal brain slices from 8- and 12-month-old male and female FDNQ175 mice. Scale bar, 300 μm for whole striatum and 50 μm for magnified areas. Data were quantified from two different 300 × 300 µm2 striatal regions of 6 sections per mouse and five independent mouse brains from each group were used for analysis. * indicates significant difference (p < 0.05)

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Molecular Brain

ISSN: 1756-6606