Fig. 5
From: Anterior cingulate cortex regulates pain catastrophizing-like behaviors in rats
Priming with noxious stimuli increases calcium spontaneous activity in the ACC. A After priming rats with noxious PP, neuronal ROIs in the ACC showed increased calcium spontaneous activity (*p < 0.05, paired t test; n = 4 animals; 546 ROIs) (Pre-Priming: 1.000 ± 0.06921, Post-Priming: 1.128 ± 0.06472). B Representative calcium traces of neuronal ROIs before and after priming. C After undergoing 5 min of rest during priming, neuronal ROIs in the ACC showed no change in calcium spontaneous activity (p = 0.44, paired t test; n = 4 animals; 500 ROIs) (Pre-Priming: 1.000 ± 0.02547, Post-Priming: 1.040 ± 0.04429). D Representative calcium traces of neuronal ROIs before and after rest. Data are represented as mean ± SEM