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Fig. 5 | Molecular Brain

Fig. 5

From: Chronic pregabalin treatment protects against spreading depolarization and alters hippocampal synaptic characteristics in a model of familial hemiplegic migraine-type 1

Fig. 5

Effect of chronic pregabalin treatment on CA1 hippocampal spontaneous excitatory postsynaptic currents recorded from S218L FHM-1 mice. a, b Chronic pregabalin (PGB) significantly decreases frequency (increases Inter-event Interval, p < 0.0001) of sEPSCs in S218L CA1 neurons. This was confirmed by analyzing both a cumulative probability plots (K-S test) and b mean values (t-test). c, d, e In S218L mice, chronic pregabalin decreases amplitude of smaller events (< 50 pA) and increases amplitude of larger (50–70 pA) events. This was confirmed by analyzing c cumulative probability plots (K-S test), d mean values (t-test) and e sEPSC event distribution. Error bars indicate ± SEM. Control = black, chronic pregabalin = grey

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Molecular Brain

ISSN: 1756-6606