Fig. 6

Effect of chronic pregabalin treatment on CA1 hippocampal spontaneous excitatory postsynaptic currents recorded from wild-type mice. a, b Chronic pregabalin (PGB) decreases frequency (increases Inter-event Interval p < 0.0001) when comparing a cumulative distributions (K-S test), but has no significant effect on b mean values (t-test). c, d Chronic pregabalin significantly decreases amplitude of sEPSCs in wild-type (WT) CA1 neurons. This was confirmed by analyzing both c cumulative probability plots (K-S test), d mean values (t-test) and e sEPSC event distribution. In wild-type-mice, chronic pregabalin increases amplitude of events (20–80 pA) and decreases amplitude of < 10 pA events and > 80 pA events. Error bars indicate ± SEM. Control = black, chronic pregabalin = grey