Chronic pregabalin treatment protects against spreading depolarization and alters hippocampal synaptic characteristics in a model of familial hemiplegic migraine-type 1

Table 2 Effects of chronic pregabalin on SD

	Effect of Chronic Lower-Dose Pregabalin vs Vehicle (Opto-Stim)
	WT		S218L
	1st SD	2nd SD	1st SD	2nd SD
Cortical SD Threshold	↔	N/A	↑	N/A
Cortical SD Speed	↔	N/A	↔	N/A
Striatal SD Invasion	↔	↓	↔	↓
Hippocampal SD Invasion	X	↓	↓	↓

Summary of effects of acute pregabalin (data taken from Cain et al. PNAS [22]) vs chronic pregabalin (data taken from current study). X = no SD in vehicle-treated animals. ↑ = increase with pregabalin, ↓ = decrease with pregabalin, ↔ = no effect of pregabalin. N/A = not applicable as cortical speed and threshold were only measured for 1st SD events

ISSN: 1756-6606