Fig. 1
From: Modulation of synaptic transmission through O-GlcNAcylation
The effects of O-GlcNAcylated proteins on synaptic plasticity. O-GlcNAcylation of CREB suppresses its transcriptional activity. Synapsin is a presynaptic protein located on the synaptic vesicular membrane. Synaptic vesicles are tethered in the RRP zone by a network composed of synapsin and actin. O-GlcNacylated synapsins may facilitate synaptic vesicle movement to the RP zone. Although the exact sites are not identified, O-GlcNAcylation of the GluA2 subunit induces endocytosis of AMPAR. OGT, O-GlcNAc transferase; OGA, O-GlcNAcase; RP, reserve pool; RRP, readily releasable pool