Skip to main content
Fig. 1 | Molecular Brain

Fig. 1

From: Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid pathology and switches astrocytes from a reactive to active state

Fig. 1

Long-term astrocytic KD of ODC1 almost completely clears Aβ plaques in APP/PS1 brains. A Schematic of the astrocytic urea cycle in Alzheimer’s Disease condition (adapted from Ju et al. [4]). B Schematic of the experimental timeline. Red arrows represent time points of virus injection. C Representative images of PyrPeg staining in the hippocampus of virus-injected APP/PS1 animals (Scale bar 200 μm). D Bar graph representing the number of plaques in the hippocampus of virus-injected APP/PS1 animals (each dot represents one brain slice, mouse N = 4–6 in each group). Data represents Mean ± SEM. *p < 0.05, **p < 0.01,***p < 0.001 (Kruskal–Wallis test and Dunn’s multiple comparisons test)

Back to article page

Molecular Brain

ISSN: 1756-6606