Fig. 5From: TREM2 improves microglia function and synaptic development in autism spectrum disorders by regulating P38 MAPK signaling pathwayTREM2 regulates microglia function through P38 MAPK pathway (A) After TREM2 interference, TREM2 mRNA expression (n = 3 for each group); (B) After TREM2 interference, TREM2 protein expression (n = 3 for each group); (C) After TREM2 overexpression, TREM2 mRNA expression (n = 3 for each group); (D) After TREM2 overexpression, TREM2 protein expression (n = 3 for each group); (E) Protein bands of TREM2 interference and overexpression; (F) IL-1β (n = 3 for each group); (G) IL-4 (n = 3 for each group); (H) PSD-95 protein expression (n = 3 for each group); (I) SYN protein expression (n = 3 for each group); (J) Gephyrin protein expression (n = 3 for each group); (K) Protein bands of PSD-95, SYN and Gephyrin; (L) CD86 protein expression (n = 3 for each group); (M) CD206 protein expression (n = 3 for each group); (N) TREM2 protein expression (n = 3 for each group); (O) p-P38 MAPK protein expression (n = 3 for each group); (P) P38 MAPK protein expression (n = 3 for each group); (Q) p-ELK-1 protein expression (n = 3 for each group); (R) ELK-1 protein expression (n = 3 for each group); (S) Protein bands of CD86, CD206, TREM2, p-P38 MAPK, P38 MAPK, p-ELK-1 and ELK-1. Data are expressed as mean ± SD. Data were analyzed using the F-test and t-test. Compared with the control group, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; Compared with the ASD group, #P < 0.05, ##P < 0.01, ###P < 0.001, ####P < 0.0001Back to article page