Fig. 7

Schematic representation of mapping the claustrum using the claustrum-enriched markers Nurr1 and Nr2f2 in combination with the claustrum-devoid cortical marker Tle4. Nurr1-expressing (Nurr1⁺) and Nr2f2-expressing (Nr2f2⁺) cells are enriched in the claustrum, but they are also found in surrounding structures. While the dense patch of Nurr1⁺ cells is found in different claustrum zones, the dense patch of Nr2f2⁺ cells maps the central zone of the claustrum. Tle4-expressing (Tle4⁺) cells are devoid from the claustrum with the exception of very few cells in the dorsal and ventral zones, and they are enriched in structures surrounding the claustrum. Juxtaposition of Nurr1⁺/Nr2f2⁺ cells with Tle4⁺ cells delineates claustrum borders. CLA claustrum, Ctx cortex, DEn dorsal endopiriform nucleus, Ins insula, Str striatum