Table 1 Behavioral test battery results of  Nlgn3^hse and Nlgn3^mf mutant mice

N = 

18

19

17

19

General health

 Body Weight (g)

26.19 ± 0.45

25.29 ± 0.70

(1)

25.31 ± 0.59

24.79 ± 0.52

(5)

 Rectal Temperature (°C)

36.86 ± 0.18

36.67 ± 0.16

(2)

35.11 ± 0.21

35.22 ± 0.24

(6)

 Wire Hang (sec)

8.21 ± 1.49

12.21 ± 4.09

(3)

10.45 ± 2.04

10.63 ± 3.06

(7)

 Grip Strength (N)

0.84 ± 0.05

0.73 ± 0.05

(4)

0.52 ± 0.05

0.48 ± 0.04

(8)

Light and dark

 Stay time (sec)

  Light

138.64 ± 13.13

123.79 ± 10.53

(9)

145.91 ± 11.11

173.34 ± 16.39

(13)

  Dark

468.94 ± 12.92

483.97 ± 10.78

(10)

462.59 ± 11.13

434.74 ± 16.02

(14)

  Transitions

24 ± 2

23 ± 2

(11)

25 ± 2

27 ± 2

(15)

  Latency to Enter Light (sec)

85.89 ± 17.76

128.68 ± 23.79

(12)

96.41 ± 17.32

87.00 ± 27.57

(16)

Open field

 Total distance (cm)

11157 ± 859

12311 ± 825

(17)

10032 ± 593

10028 ± 980

(21)

 Center Time (sec)

1836 ± 248

2073 ± 256

(18)

1386 ± 204

918 ± 139

(22)

 Stereotypic Activity

12,344 ± 674

13368 ± 1014

(19)

11138 ± 790

10007 ± 739

(23)

 Vertical Activity

1658 ± 220

1650 ± 209

(20)

1189 ± 153

980 ± 110

(24)

Elevated Plus Maze

 Number of Entries-Total

43.11 ± 2.46

38.68 ± 1.43

(25)

47.71 ± 2.55

55.79 ± 2.89

(28)

 Open Arm Entry (%)

24.49 ± 2.42

25.88 ± 2.42

(26)

25.83 ± 2.73

35.57 ± 3.17

(29)

 Open Arm Stay Time (%)

8.53 ± 1.59

10.41 ± 1.85

(27)

9.66 ± 1.5

20.49 ± 3.19

(30)

Hot plate

 Latency (sec)

5.29 ± 0.3

5.79 ± 0.47

(31)

5.11 ± 0.26

5.45 ± 0.31

(32)

Prepulse (PP) inhibition

 N = 

16

18

17

19

 Startle Amplitude (SA) 110 dB

1.41 ± 0.18

1.52 ± 0.19

(33)

1.79 ± 0.17

1.53 ± 0.16

(39)

 SA 120 dB

1.65 ± 0.27

1.68 ± 0.24

(34)

1.89 ± 0.2

1.76 ± 0.20

(40)

 PPSoundlevel (PPS) 74 dB–SA110dB

27.58 ± 4.95

41.13 ± 6.22

(35)

30.85 ± 7.07

32.14 ± 5.66

(41)

 PPS74dB–SA120dB

14.56 ± 6.74

22.64 ± 8.12

(36)

25.13 ± 7.45

31.34 ± 6.23

(42)

 PPS78dB–SA110dB

47.7 ± 3.86

56.01 ± 5.41

(37)

48.01 ± 6.06

48.20 ± 5.67

(43)

 PPS78dB–SA120dB

37.5 ± 5.56

48.77 ± 6.6

(38)

41.23 ± 5.87

454.42 ± 5.96

(44)

Porsolt forced swim

 N = 

18

19

17

19

 Immobility (%) Day1

48.91 ± 2.41

45.03 ± 2.50

(45)

46.468 ± 2.57

46.30 ± 1.94

(49)

 Immobility (%) Day2

58.32 ± 4.30

57.01 ± 2.61

(46)

60.91 ± 2.44

59.86 ± 1.63

(50)

 Total distance (cm) Day1

733.82 ± 38.62

732.38 ± 31.41

(47)

722.50 ± 30.67

704.19 ± 25.87

(51)

 Total distance (cm) Day2

541.68 ± 104.43

474.42 ± 23.57

(48)

418.65 ± 25.80

449.48 ± 21.86

(52)