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Midbrain dopaminergic neuron fate specification: Of mice and embryonic stem cells

The midbrain dopaminergic (mDA) neurons of the substantia nigra and the ventral tegmental area play a fundamental role in the control of voluntary movement and the regulation of emotion, and are severely affec...

Authors: Emily Gale and Meng Li

Citation: Molecular Brain 2008 1:8

Content type: Review Published on: 30 September 2008
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Comprehensive behavioral phenotyping of calpastatin-knockout mice

Calpastatin is an endogenous inhibitor of calpain, intracellular calcium-activated protease. It has been suggested to be involved in molecular mechanisms of long-term plasticity and excitotoxic pathways. Howev...

Authors: Ryuichi Nakajima, Keizo Takao, Shu-Ming Huang, Jiro Takano, Nobuhisa Iwata, Tsuyoshi Miyakawa and Takaomi C Saido

Citation: Molecular Brain 2008 1:7

Content type: Research Published on: 15 September 2008
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Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders

Elucidating the neural and genetic factors underlying psychiatric illness is hampered by current methods of clinical diagnosis. The identification and investigation of clinical endophenotypes may be one soluti...

Authors: Nobuyuki Yamasaki, Motoko Maekawa, Katsunori Kobayashi, Yasushi Kajii, Jun Maeda, Miho Soma, Keizo Takao, Koichi Tanda, Koji Ohira, Keiko Toyama, Kouji Kanzaki, Kohji Fukunaga, Yusuke Sudo, Hiroshi Ichinose, Masashi Ikeda, Nakao Iwata…

Citation: Molecular Brain 2008 1:6

Content type: Research Published on: 10 September 2008
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Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia?

Using an endophenotype-driven screen, a new study finds that α-calcium/calmodulin kinase II mutant mice exhibit a range of behavioral abnormalities related to schizophrenia. Perhaps most strikingly, this clust...

Authors: Paul W Frankland, Masanori Sakaguchi and Maithé Arruda-Carvalho

Citation: Molecular Brain 2008 1:5

Content type: Editorial Published on: 10 September 2008
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Atypical evening cortisol profile induces visual recognition memory deficit in healthy human subjects

Diurnal rhythm-mediated endogenous cortisol levels in humans are characterised by a peak in secretion after awakening that declines throughout the day to an evening trough. However, a significant proportion of...

Authors: Heather Gilpin, Daniel Whitcomb and Kwangwook Cho

Citation: Molecular Brain 2008 1:4

Content type: Research Published on: 21 August 2008
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Transcriptional regulation of long-term memory in the marine snail Aplysia

Whereas the induction of short-term memory involves only covalent modifications of constitutively expressed preexisting proteins, the formation of long-term memory requires gene expression, new RNA, and new pr...

Authors: Yong-Seok Lee, Craig H Bailey, Eric R Kandel and Bong-Kiun Kaang

Citation: Molecular Brain 2008 1:3

Content type: Review Published on: 17 June 2008
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Cingulate NMDA NR2B receptors contribute to morphine-induced analgesic tolerance

Morphine is widely used to treat chronic pain, however its utility is hindered by the development of tolerance to its analgesic effects. While N-methyl-D-aspartate (NMDA) receptors are known to play roles in m...

Authors: Shanelle W Ko, Long-Jun Wu, Fanny Shum, Jessica Quan and Min Zhuo

Citation: Molecular Brain 2008 1:2

Content type: Research Published on: 17 June 2008
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Welcome to Molecular Brain

We are delighted to announce the arrival of a brand new journal dedicated to the ever-expanding field of neuroscience. Molecular Brain is a peer-reviewed, open-access online journal that aims at publishing high q...

Authors: Lin Mei, Kei Cho, C Justin Lee, Xiao-Jiang Li, Min Zhuo and Bong-Kiun Kaang

Citation: Molecular Brain 2008 1:1

Content type: Editorial Published on: 17 June 2008
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Articles

Midbrain dopaminergic neuron fate specification: Of mice and embryonic stem cells

Comprehensive behavioral phenotyping of calpastatin-knockout mice

Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders

Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia?

Atypical evening cortisol profile induces visual recognition memory deficit in healthy human subjects

Transcriptional regulation of long-term memory in the marine snail Aplysia

Cingulate NMDA NR2B receptors contribute to morphine-induced analgesic tolerance

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