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  1. Coenzyme Q8A encodes the homologue of yeast coq8, an ATPase that is required for the biosynthesis of Coenzyme Q10, an essential component of the electron transport chain. Mutations in COQ8A in humans result in Co...

    Authors: Angelia J. Hura, Hannah R. Hawley, Wei Jun Tan, Rebecca J. Penny, Jessie C. Jacobsen and Helen L. Fitzsimons
    Citation: Molecular Brain 2022 15:15
  2. Ischemic stroke, caused by a lack of blood supply in brain tissues, is the third leading cause of human death and disability worldwide, and usually results in sensory and motor dysfunction, cognitive impairmen...

    Authors: Weichen Hou, Yulei Hao, Li Sun, Yang Zhao, Xiangyu Zheng and Lei Song
    Citation: Molecular Brain 2022 15:14
  3. Retrograde tracers based on viral vectors are powerful tools for the imaging and manipulation of upstream neural networks projecting to a specific brain region, and they play important roles in structural and ...

    Authors: Zengpeng Han, Nengsong Luo, Jiaxin Kou, Lei Li, Zihong Xu, Siyuan Wei, Yang Wu, Jie Wang, Chaohui Ye, Kunzhang Lin and Fuqiang Xu
    Citation: Molecular Brain 2022 15:13
  4. Chronic pain damages the balance between excitation and inhibition in the sensory cortex. It has been confirmed that the activity of cortical glutamatergic pyramidal cells increases after chronic pain. However...

    Authors: Da-Yu Zhu, Ting-Ting Cao, Hong-Wei Fan, Ming-Zhe Zhang, Hao-Kai Duan, Jing Li, Xia-Jing Zhang, Yun-Qing Li, Pan Wang and Tao Chen
    Citation: Molecular Brain 2022 15:12
  5. Emerging evidence suggests that the mesolimbic dopaminergic network plays a role in the modulation of pain. As chronic pain conditions are associated with hypodopaminergic tone in the nucleus accumbens (NAc), ...

    Authors: Daisuke Sato, Michiko Narita, Yusuke Hamada, Tomohisa Mori, Kenichi Tanaka, Hideki Tamura, Akihiro Yamanaka, Ryosuke Matsui, Dai Watanabe, Yukari Suda, Emiko Senba, Moe Watanabe, Edita Navratilova, Frank Porreca, Naoko Kuzumaki and Minoru Narita
    Citation: Molecular Brain 2022 15:10
  6. Bipolar disorder (BD) is a severe psychiatric disorder characterized by repeated conflicting manic and depressive states. In addition to genetic factors, complex gene–environment interactions, which alter the ...

    Authors: Hiroko Sugawara, Miki Bundo, Takaoki Kasahara, Yutaka Nakachi, Junko Ueda, Mie Kubota-Sakashita, Kazuya Iwamoto and Tadafumi Kato
    Citation: Molecular Brain 2022 15:9
  7. Myocyte Enhancer Factor 2 C (MEF2C), one of the transcription factors of the MADS-BOX family, is involved in embryonic brain development, neuronal formation and differentiation, as well as in the growth and pr...

    Authors: Zhikun Zhang and Yongxiang Zhao
    Citation: Molecular Brain 2022 15:8
  8. Systems neuroscience is focused on how ensemble properties in the brain, such as the activity of neuronal circuits, gives rise to internal brain states and behavior. Many of the studies in this field have trad...

    Authors: Yang Shen, Alessandro Luchetti, Giselle Fernandes, Won Do Heo and Alcino J. Silva
    Citation: Molecular Brain 2022 15:7
  9. It is well known that acute exposure to physical stress produces a transient antinociceptive effect (called stress-induced analgesia [SIA]). One proposed mechanism for SIA involves noradrenaline (NA) in the ce...

    Authors: Sawako Uchiyama, Kohei Yoshihara, Riku Kawanabe, Izuho Hatada, Keisuke Koga and Makoto Tsuda
    Citation: Molecular Brain 2022 15:6
  10. Soluble amyloid precursor protein-alpha (sAPPα) is a regulator of neuronal and memory mechanisms, while also having neurogenic and neuroprotective effects in the brain. As adult hippocampal neurogenesis is imp...

    Authors: Shane M. Ohline, Connie Chan, Lucia Schoderboeck, Hollie E. Wicky, Warren P. Tate, Stephanie M. Hughes and Wickliffe C. Abraham
    Citation: Molecular Brain 2022 15:5
  11. Escherichia coli is the most common gram-negative pathogenic bacterium causing meningitis. It penetrates the blood–brain barrier (BBB) and activates nuclear factor kappa B (NF-κB) signaling, which are vital event...

    Authors: Bojie Xu, Ruicheng Yang, Bo Yang, Liang Li, Jiaqi Chen, Jiyang Fu, Xinyi Qu, Dong Huo, Chen Tan, Huanchun Chen, Zhong Peng and Xiangru Wang
    Citation: Molecular Brain 2022 15:4
  12. Low-voltage-activated T-type Ca2+ channels are key regulators of neuronal excitability both in the central and peripheral nervous systems. Therefore, their recruitment at the plasma membrane is critical in determ...

    Authors: Leos Cmarko, Robin N. Stringer, Bohumila Jurkovicova-Tarabova, Tomas Vacik, Lubica Lacinova and Norbert Weiss
    Citation: Molecular Brain 2022 15:1
  13. Brain metastasis is a common and lethal complication of non-small cell lung cancer (NSCLC). It is mostly diagnosed only after symptoms develop, at which point very few treatment options are available. Therefor...

    Authors: Yanjun Xu, Zhiyu Huang, Xiaoqing Yu, Kaiyan Chen and Yun Fan
    Citation: Molecular Brain 2021 14:176
  14. Ketamine, a non-competitive antagonist of the N-methyl-d-aspartate receptor (NMDAR), generates a rapidly-acting antidepressant effect. It exerts psychomimetic effects, yet demands a further investigation of its m...

    Authors: Dae Hee Han, Ilgang Hong, Ja Eun Choi, Pojeong Park, Jun-Yeong Baek, HyoJin Park, Soichiro Ide, Masayoshi Mishina, Kazutaka Ikeda and Bong-Kiun Kaang
    Citation: Molecular Brain 2021 14:174
  15. Dopamine (DA) and norepinephrine (NE) are pivotal neuromodulators that regulate a broad range of brain functions, often in concert. Despite their physiological importance, untangling the relationship between D...

    Authors: Chihiro Nakamoto, Yuhei Goto, Yoko Tomizawa, Yuko Fukata, Masaki Fukata, Kasper Harpsøe, David E. Gloriam, Kazuhiro Aoki and Tomonori Takeuchi
    Citation: Molecular Brain 2021 14:173
  16. Despite the established roles of the dopaminergic system in promoting arousal, the effects of loss of dopamine on the patterns of sleep and wakefulness remain elusive. Here, we examined the sleep architecture ...

    Authors: Mitsuaki Kashiwagi, Mika Kanuka, Kaeko Tanaka, Masayo Fujita, Ayaka Nakai, Chika Tatsuzawa, Kazuto Kobayashi, Kazutaka Ikeda and Yu Hayashi
    Citation: Molecular Brain 2021 14:170
  17. Rho-associated kinase isoform 2 (ROCK2) is an attractive drug target for several neurologic disorders. A critical barrier to ROCK2-based research and therapeutics is the lack of a mouse model that enables inve...

    Authors: Audrey J. Weber, Ashley B. Adamson, Kelsey M. Greathouse, Julia P. Andrade, Cameron D. Freeman, Jung Vin Seo, Rosaria J. Rae, Courtney K. Walker and Jeremy H. Herskowitz
    Citation: Molecular Brain 2021 14:169
  18. Avoidance memory is destabilized when recalled concurrently with conflicting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/...

    Authors: Andressa Radiske, Maria Carolina Gonzalez, Janine I. Rossato, Gênedy Apolinário, João R. de Oliveira, Lia R. M. Bevilaqua and Martín Cammarota
    Citation: Molecular Brain 2021 14:167
  19. T-type calcium channels are known molecular targets of certain phytocannabinoids and endocannabinoids. Here we explored the modulation of Cav3.2 T-type calcium channels by terpenes derived from cannabis plants...

    Authors: Vinicius M. Gadotti, Sun Huang and Gerald W. Zamponi
    Citation: Molecular Brain 2021 14:166
  20. REM sleep behaviour disorder (RBD) can be an early non-motor symptom of Parkinson’s disease (PD) with pathology involving mainly the pontine nuclei. Beyond the brainstem, it is unclear if RBD patients comorbid...

    Authors: Mikaeel Valli, Sang Soo Cho, Carme Uribe, Mario Masellis, Robert Chen, Alexander Mihaescu and Antonio P. Strafella
    Citation: Molecular Brain 2021 14:165
  21. Authors: Adan Hernandez, Chunfeng Tan, Florian Plattner, Aric F. Logsdon, Karine Pozo, Mohammad A. Yousuf, Tanvir Singh, Ryan C. Turner, Brandon P. Lucke-Wold, Jason D. Huber, Charles L. Rosen and James A. Bibb
    Citation: Molecular Brain 2021 14:164

    The original article was published in Molecular Brain 2018 11:64

  22. We have reported that the transcription factor Olig2 labels a subpopulation of astrocytes (Olig2-astrocytes), which show distribution patterns different from those of GFAP-expressing astrocytes (GFAP-astrocyte...

    Authors: Kouko Tatsumi, Kaoru Kinugawa, Ayami Isonishi, Masahiro Kitabatake, Hiroaki Okuda, Shoko Takemura, Tatsuhide Tanaka, Eiichiro Mori and Akio Wanaka
    Citation: Molecular Brain 2021 14:163
  23. Molecular and cellular mechanisms underlying the role of the prelimbic cortex in contextual fear memory remain elusive. Here we examined the kinesin family of molecular motor proteins (KIFs) in the prelimbic c...

    Authors: Nadine F. Joseph, Aya Zucca, Jenna L. Wingfield, Isabel Espadas, Damon Page and Sathyanarayanan V. Puthanveettil
    Citation: Molecular Brain 2021 14:162
  24. Parkinson’s disease (PD) is a multi-system neurodegenerative disorder. Patients with PD often suffer chronic pain. In the present study, we investigated motor, sensory and emotional changes in three different ...

    Authors: Zhaoxiang Zhou, Penghai Ye, Xu-Hui Li, Yuxiang Zhang, Muhang Li, Qi-Yu Chen, Jing-Shan Lu, Man Xue, Yanan Li, Weiqi Liu, Lin Lu, Wantong Shi, Ping-Yi Xu and Min Zhuo
    Citation: Molecular Brain 2021 14:161

    The Correction to this article has been published in Molecular Brain 2022 15:58

  25. Songbirds are one of the few animal taxa that possess vocal learning abilities. Different species of songbirds exhibit species-specific learning programs during song acquisition. Songbirds with open-ended voca...

    Authors: Shin Hayase, Chengru Shao, Masahiko Kobayashi, Chihiro Mori, Wan-chun Liu and Kazuhiro Wada
    Citation: Molecular Brain 2021 14:160
  26. Neuroinflammation is an escalation factor shared by a vast range of central nervous system (CNS) pathologies, from neurodegenerative diseases to neuropsychiatric disorders. CNS immune status emerges by the int...

    Authors: Giulia Panattoni, Roberta Amoriello, Christian Memo, Agnes Thalhammer, Clara Ballerini and Laura Ballerini
    Citation: Molecular Brain 2021 14:159
  27. Alterations in the canonical processing of Amyloid Precursor Protein generate proteoforms that contribute to the onset of Alzheimer’s Disease. Modified composition of γ-secretase or mutations in its subunits h...

    Authors: Shekhar Kedia, Kousik Mandal, Pallavi Rao Netrakanti, Mini Jose, Sangram S. Sisodia and Deepak Nair
    Citation: Molecular Brain 2021 14:158
  28. Growth hormone secretagogue receptor 1a (GHS-R1a) is widely distributed in brain including the hippocampus. Studies have demonstrated the critical role of hippocampal ghrelin/GHS-R1a signaling in synaptic phys...

    Authors: Nan Li, Na Li, Fenghua Xu, Ming Yu, Zichen Qiao and Yu Zhou
    Citation: Molecular Brain 2021 14:157
  29. The neuro-physiological properties of individuals with genetic pre-disposition to neurological disorders are largely unknown. Here we aimed to explore these properties using cerebral organoids (COs) derived fr...

    Authors: Simote T. Foliaki, Benjamin Schwarz, Bradley R. Groveman, Ryan O. Walters, Natalia C. Ferreira, Christina D. Orrù, Anna Smith, Aleksandar Wood, Olivia M. Schmit, Phoebe Freitag, Jue Yuan, Wenquan Zou, Catharine M. Bosio, James A. Carroll and Cathryn L. Haigh
    Citation: Molecular Brain 2021 14:156
  30. Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease, with no present cure. The progressive loss of MNs is the hallmark of ALS. We have previously shown the therapeutic effects of t...

    Authors: Junmei Wang, Lydia Tierney, Ranjeet Mann, Thomas Lonsway and Chandler L. Walker
    Citation: Molecular Brain 2021 14:155
  31. The generation of mature synaptic structures using neurons differentiated from human-induced pluripotent stem cells (hiPSC-neurons) is expected to be applied to physiological studies of synapses in human cells...

    Authors: Kazuyuki Togo, Hayato Fukusumi, Tomoko Shofuda, Hiroshi Ohnishi, Hiroyuki Yamazaki, Mariko Kato Hayashi, Nana Kawasaki, Nobuyuki Takei, Takanobu Nakazawa, Yumiko Saito, Kousuke Baba, Hitoshi Hashimoto, Yuko Sekino, Tomoaki Shirao, Hideki Mochizuki and Yonehiro Kanemura
    Citation: Molecular Brain 2021 14:149
  32. Studies on the development of central nervous system (CNS) primarily rely on the use of specific molecular markers for different types of neural cells. S100B is widely being used as a specific marker for astro...

    Authors: Junqing Du, Min Yi, Fang Zhou, Wanjun He, Aifen Yang, Mengsheng Qiu and Hao Huang
    Citation: Molecular Brain 2021 14:154
  33. Fear conditioning and retrieval are suitable models to investigate the biological basis of various mental disorders. Hippocampus and amygdala neurons consolidate conditioned stimulus (CS)-dependent fear memory...

    Authors: Yoonjeong Jeon, Yun Lim, Jiwoo Yeom and Eun-Kyoung Kim
    Citation: Molecular Brain 2021 14:153
  34. The glutamatergic signaling pathway is involved in molecular learning and human cognitive ability. Specific single variants (SNVs, formerly single-nucleotide polymorphisms) in the genes encoding N-methyl-d-aspart...

    Authors: Li-Ching Lee, Ming-Tsan Su, Hsing-Ying Huang, Ying-Chun Cho, Ting-Kuang Yeh and Chun-Yen Chang
    Citation: Molecular Brain 2021 14:152
  35. The atypical chemokine receptor 3, ACKR3, is a G protein-coupled receptor, which does not couple to G proteins but recruits βarrestins. At present, ACKR3 is considered a target for cancer and cardiovascular di...

    Authors: Aliza T. Ehrlich, Meriem Semache, Pierre Couvineau, Stefan Wojcik, Hiroyuki Kobayashi, Marcus Thelen, Florence Gross, Mireille Hogue, Christian Le Gouill, Emmanuel Darcq, Michel Bouvier and Brigitte L. Kieffer
    Citation: Molecular Brain 2021 14:151
  36. Post-traumatic stress disorder (PTSD) is a trauma-related disorder that is associated with pro-inflammatory activation and neurobiological impairments in the brain and leads to a series of affective-like behav...

    Authors: Yi-Hung Chen, Sheng-Yun Xie, Chao-Wei Chen and Dah-Yuu Lu
    Citation: Molecular Brain 2021 14:150
  37. The Cre/LoxP-based conditional knockout technology is a powerful tool for gene function analysis that allows region- and time-specific gene manipulation. However, inserting a pair of LoxP cassettes to generate...

    Authors: Hirofumi Nishizono, Yuki Hayano, Yoshihisa Nakahata, Yasuhito Ishigaki and Ryohei Yasuda
    Citation: Molecular Brain 2021 14:148
  38. Hypoxia typically accompanies acute inflammatory responses in patients and animal models. However, a limited number of studies have examined the effect of hypoxia in combination with inflammation (Hypo-Inf) on...

    Authors: Yoon-Sil Yang, Joon Ho Choi and Jong-Cheol Rah
    Citation: Molecular Brain 2021 14:147
  39. Chronic postsurgical pain (CPSP) is a serious problem. We developed a mouse model of CPSP induced by electrocautery and examined the mechanism of CPSP. In this mouse model, while both incision and electrocaute...

    Authors: Yosuke Katsuda, Kenichi Tanaka, Tomohisa Mori, Michiko Narita, Hideyuki Takeshima, Takashige Kondo, Yoshiyuki Yamabe, Misa Matsufuji, Daisuke Sato, Yusuke Hamada, Keisuke Yamaguchi, Toshikazu Ushijima, Eiichi Inada, Naoko Kuzumaki, Masako Iseki and Minoru Narita
    Citation: Molecular Brain 2021 14:146
  40. Astrocytes express a plethora of G protein-coupled receptors (GPCRs) that are crucial for shaping synaptic activity. Upon GPCR activation, astrocytes can respond with transient variations in intracellular Ca2+. I...

    Authors: Yana Van Den Herrewegen, Thomas M. Sanderson, Surajit Sahu, Dimitri De Bundel, Zuner A. Bortolotto and Ilse Smolders
    Citation: Molecular Brain 2021 14:144
  41. Vacuolar protein sorting 35 (VPS35) regulates neurotransmitter receptor recycling from endosomes. A missense mutation (D620N) in VPS35 leads to autosomal-dominant, late-onset Parkinson’s disease. Here, we stud...

    Authors: Chelsie A. Kadgien, Anusha Kamesh and Austen J. Milnerwood
    Citation: Molecular Brain 2021 14:143
  42. Arginine vasopressin (AVP) is expressed in both hypothalamic and extra-hypothalamic neurons. The expression and role of AVP exhibit remarkable divergence between these two neuronal populations. Polysynaptic pa...

    Authors: Wen Han Tong, Samira Abdulai-Saiku and Ajai Vyas
    Citation: Molecular Brain 2021 14:141

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