Figure 3
From: DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze
Altered synaptic properties in DIP/WISH-deficientmice. (A) Comparison of the field excitatory postsynaptic potential (fEPSP) slopes as a function of stimulation intensities revealed a significant difference (P < 0.01) between DIP/WISH knockout (n = 5) and wild-type slices (n = 6) in the range of higher stimulation intensities applied (150 and 200 μA respectively; as indicated by asterisks). (B) Paired-pulse facilitation (PPF), a short-term form of presynaptic plasticity, is notably altered in DIP knockout mice. PPF at intervals of 25, 50, 100, 300 and 1000 ms revealed a significant difference (P < 0.05; as indicated by asterisks) between DIP mutants (n = 5) and wild-type animals (n = 5).