Figure 1

TatCN21 reverses LTP. fEPSPs recorded from the CA1 region of a hippocampal slice. At 20 min, LTP was induced by four tetani. This LTP was saturated, as evidenced by lack of further potentiation when an additional tetanus was given at 40 min. tatCN21 was then applied for 30 min. Upon removal, there was partial recovery, but also a non-recoverable component that demonstrates LTP reversal. To verify that saturated LTP had indeed been reversed, an additional tetanus was given (right), and this reinduced LTP. In control experiments without tatCN21 application, LTP could not be reinduced.