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Figure 3 | Molecular Brain

Figure 3

From: Upregulation of excitatory neurons and downregulation of inhibitory neurons in barrel cortex are associated with loss of whisker inputs

Figure 3

A loss of whisker input upregulates the signal transmission of excitatory synapses on pyramidal neurons of the barrel cortex. The strength of excitatory synapses was evaluated by recording spontaneous excitatory postsynaptic currents (sEPSC) in presence of 10 μM bicuculline, which were blocked by 10 μM CNQX and 40 μM D-AP5. A) illustrates sEPSCs recorded on a pyramidal neuron in the barrel cortex of a control mouse. B) illustrates sEPSCs recorded on a pyramidal neuron in the barrel cortex from a whisker-trimmed mouse. Calibration bars are 15 pA/3 seconds C) illustrates cumulative probability versus sEPSC amplitudes in barrel cortical pyramidal neurons from whisker-trimmed mice (open symbols, n=11) and controls (filled, n=12). D) illustrates cumulative probability versus inter-EPSC intervals in barrel cortical pyramidal neurons from whisker-trimmed mice (open symbols, n=11) and controls (filled, n=12).

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Molecular Brain

ISSN: 1756-6606