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Figure 4 | Molecular Brain

Figure 4

From: Expression of NMDA receptor-dependent LTP in the hippocampus: bridging the divide

Figure 4

A mechanism for postsynaptic AMPA receptor trafficking in LTP. A. A scheme showing that NMDA receptor activation leads to the activation of PKMĪ¶ which stabilizes AMPA receptors at the synapse by promoting the interaction between the GluA2 subunit and N-ethylmaleimide-sensitive factor (NSF). B. ZIP, a peptide that inhibits the activity of PKMĪ¶, inhibits the expression of LTP many hours after its induction. From [85]. C. Pep2m, a peptide that blocks the GluA2-NSF interaction, also inhibits the expression of LTP. From [83].

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