Figure 4
From: Expression of NMDA receptor-dependent LTP in the hippocampus: bridging the divide
A mechanism for postsynaptic AMPA receptor trafficking in LTP. A. A scheme showing that NMDA receptor activation leads to the activation of PKMζ which stabilizes AMPA receptors at the synapse by promoting the interaction between the GluA2 subunit and N-ethylmaleimide-sensitive factor (NSF). B. ZIP, a peptide that inhibits the activity of PKMζ, inhibits the expression of LTP many hours after its induction. From [85]. C. Pep2m, a peptide that blocks the GluA2-NSF interaction, also inhibits the expression of LTP. From [83].